TERMS AND CONDITIONS OF USE:
Access to and use of this web site is subject to these Terms and Conditions of use and all applicable laws and regulations. Please read these Terms and Conditions of use carefully. Your use of this web site constitutes your acceptance of these Terms and Conditions. If you do not agree to abide by all of the provisions contained in these Terms and Conditions, you must not use or access the web site. These Terms and Conditions may also be changed, such changes which will be posted to this page and will become effective immediately upon posting. For this reason, you are urged to read Terms and Conditions each time you visit this web site. These Terms and Conditions were last updated August, 2007.
Copyright and Trademark Information
This web site, and the content which it contains, is the property of NitroMed, Inc. ("NitroMed") and its affiliates and licensors, and is protected from unauthorized copying and dissemination by United States copyright law, trademark law, international conventions and other intellectual property laws. NitroMed®, BiDil®, More Life to Live™, NitroMed Cares™, and the "N" design are registered trademarks or trademarks of NitroMed, Inc. in the United States and other countries.
All other product names are trademarks or registered trademarks of their respective owners.
Use of BiDil.com Web Site and Its Content
NitroMed may alter, suspend, or discontinue this web site at any time for any reason, without notice or cost or obligation to any person. The web site may become unavailable due to maintenance or malfunction of computer equipment or other reasons.
You may download, view, copy and print content, subject to the following:
- content may be used solely for personal, informational, or internal business purposes;
- any and all copyright, trademark and other proprietary rights notices must appear on all copies, including the copyright notice at the bottom of the page;
- the content may not be modified or altered in any way; and
- no graphics may be used separate from accompanying text.
Except as provided above, you may not use, download, upload, copy, print, display, perform, reproduce, publish, license, post, transmit, frame, mirror on another web service, use any meta tags, inline any graphics or distribute any content or information from the web site in whole or in part without the express permission of NitroMed. Requests for permission to use content other than provided above should be made to info@nitromed.com. Any rights not expressly granted herein are reserved. Please be advised that NitroMed enforces its intellectual property rights to the fullest extent of the law.
Certain product, service, or company designations for companies other than NitroMed may be mentioned in the web site for identification purposes only. You should contact the appropriate companies for more complete information regarding such designations and their registration status.
Nothing contained on this web site should be construed as granting, by implication, estoppel, or otherwise, any license or right to use this web site or any content or documents displayed on this web site, through the use of framing or otherwise, except: (a) as expressly permitted by these terms and conditions; or (b) with the prior written permission of NitroMed or such third party that may own the trademark or copyright of material displayed on this web site.
No Medical Advice
The information contained throughout this web site is provided by NitroMed for informational purposes only. The information on this web site is not intended to take the place of professional medical care, or professional medical advice or to constitute a treatment recommendation. If you have, or suspect you have, a medical condition, you should consult with your physician or another qualified health care provider. Although NitroMed will use reasonable efforts to include accurate and up-to-date information on this site, it makes no warranties or representations as to its accuracy.
No Warranties
Information and documents provided on this web site are provided "as is" without warranties of any kind, whether express or implied, including, but not limited to warranties of title or implied warranties of merchantability or fitness for a particular purpose, other than those warranties which are imposed by and incapable of exclusion, restriction or modification under the laws applicable to this agreement. Specifically, but without limitation, NitroMed does not warrant that: (I) The information on this web site is correct, accurate, reliable or complete, (II) the functions contained on this web site will be uninterrupted or error-free; (III) defects will be corrected, or (IV) this web site or the server(s) that makes it available are free of viruses or other harmful components. It is the user's responsibility to ascertain whether any information downloaded from this web site is free of viruses, worms, Trojan horses, or other items of a potentially destructive nature.
Limitation of Liability
Under no circumstances shall NitroMed nor any of its affiliates, subsidiaries, agents or representatives be liable to you or anyone else for any direct, indirect, incidental, special, punitive, consequential, exemplary, multiple or other indirect damages incurred by you or any third party, whether in an action in contract or in tort, arising from access to, the use of, or the inability to use, this web site or the information contained on this web site, even if NitroMed has been advised of the possibility of such damages. Some jurisdictions do not allow the limitation or exclusion of liability. Accordingly, some of the above limitations may not apply to you.
Links to Third-Party Web Sites
These Terms and Conditions apply only to www.nitromed.com. This web site may contain links to non-NitroMed web sites. Please refer to the separate terms of use, privacy policies, and other rules posted on these linked web sites before you use them. These links are provided to you as a convenience, and the inclusion of any link does not imply affiliation or endorsement by NitroMed. NitroMed does not review, monitor or check the accuracy of content published on third party web sites, and is not responsible for the availability of, and content provided on, third party web sites. Third party web sites may contain information about uses of products that have not been approved or cleared by the U.S. Food and Drug Administration. NitroMed does not endorse the off-label use of any of our products.
No Implied Endorsements
In no event shall any reference to any third party or third party product or service be construed as an approval or endorsement by NitroMed of that third party or of any product or service provided by a third party. If you choose to purchase any products or services from a third party, your relationship is directly with the third party and NitroMed is not responsible for any loss or damage of any sort you may incur from dealing with any third party.
Jurisdictional Issues
NitroMed makes no representation that information on this web site is appropriate or available for use outside the United States. Those who choose to access this web site from outside the United States do so on their own initiative and are responsible for compliance with local laws, if and to the extent local laws are applicable.
Enforcement of Terms and Conditions
These Terms and Conditions are governed and interpreted pursuant to the laws of the Commonwealth of Massachusetts, United States of America, notwithstanding any principles of conflicts of law.
All disputes arising out of or relating to these Terms and Conditions shall be finally resolved by arbitration conducted in the English language in Boston, Massachusetts, U.S.A. under the commercial arbitration rules of the American Arbitration Association. The parties shall appoint as sole arbitrator a retired judge who presided in the Commonwealth of Massachusetts. The parties shall bear equally the cost of the arbitration (except that the prevailing party shall be entitled to an award of reasonable attorneys' fees incurred in connection with the arbitration in such an amount as may be determined by the arbitrator). All decisions of the arbitrator shall be final and binding on both parties and enforceable in any court of competent jurisdiction. Notwithstanding this, application may be made to any court for a judicial acceptance of the award or order of enforcement. Notwithstanding the foregoing, NitroMed shall be entitled to seek injunctive relief, security, or other equitable remedies from the United States District Court for the District of Massachusetts or any other court of competent jurisdiction.
If any part of these terms is unlawful, void, or unenforceable, that part will be deemed severable and will not affect the validity and enforceability of the remaining provisions. NitroMed may, at its sole discretion and without notice, revise these terms at any time by updating this posting.
Entire Agreement
These Terms and Conditions, the Privacy Policy, any operating rules, policies, or procedures that may be posted from time to time by NitroMed on this web site, and any modifications to the foregoing, constitute the entire Agreement between the parties relating to the subject matter herein and supersede all prior understandings and agreements, whether written or oral, as to such subject matter.
NitroMed may assign its rights and duties under these Terms and Conditions without such assignment being considered a change to the Terms and Conditions and without notice to you. You may not assign these Terms and Conditions without the prior written consent of NitroMed.
Acknowledgment
By accessing this web site, you agree to all the terms and conditions of the Terms and Conditions. You acknowledge (a) that you have read and understood the Terms and Conditions; and (b) that these Terms and Conditions have the same force and effect as a signed agreement.
For Additional Information
If you have any questions about the rights and restrictions above, please contact NitroMed at info@nitromed.com.
Important information about BiDil®
(isosorbide dinitrate/hydralazine hydrochloride):
INDICATIONS AND USAGE
BiDil is indicated for the treatment of heart failure as an adjunct to standard therapy in self-identified black patients to improve survival, to prolong time to hospitalization for heart failure, and to improve patient reported functional status. There is little experience in patients with NYHA class IV heart failure. Most patients in the clinical trial supporting effectiveness (A-HeFT) received a loop diuretic, an angiotensin converting enzyme inhibitor or an angiotensin II receptor blocker, and a beta blocker, and many also received a cardiac glycoside or an aldosterone antagonist.
CONTRAINDICATIONS
BiDil is contraindicated in patients who are allergic to organic nitrates.
WARNINGS
Augmentation of the vasodilatory effects of isosorbide dinitrate by phosphodiesterase inhibitors such as sildenafil, vardenafil, or tadalafil could result in severe hypotension. The time course and dose dependence of this interaction have not been studied. Reasonable supportive care should consist of those measures used to treat a nitrate overdose with elevation of the extremities and central volume expansion.
ADVERSE REACTIONS
Adverse events reported in A-HeFT and seen more frequently in the group given BiDil included headache (50% in BiDil patients vs. 21% in placebo patients) and dizziness (32% in BiDil patients vs. 14% in placebo patients).
The full Prescribing Information for BiDil is available here.
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